Best clinics of Treatment of Retinitis Pigmentosa in Turkey

Thanks to many innovative treatments that prevent blindness and eye diseases, vision loss is about to become history. One of the most common diseases that lead to visual impairment is the Retinitis Pigmentosa, RP.

The Retinite Pigmentosa (RP) is the degeneration of the photoreceptors (cones and rods). It is also known as pigmentary retinopathy, tapetoretinal degeneration and rod-cone dystrophy.

The patient, who suffer from rods’ deficiency, experiences visual impairment in the dark, especially when going from luminous to dark environments. A simple eye exam would help to detect the presence of degenerative cells in the retina.


What Causes rod-cone dystrophy

There are several factors that may lead to the onset and the development of a pigmentary retinopathy. The main causes of retinitis pigmentosa (rod-cone dystrophy) can be:

Heredity

Retinitis pigmentosa is a genetic condition that affects both eyes. Transmission can be transmitted in about 50% of patients with predominantly autosomal recessive or dominant transmission. About 10% of patients have a transmission on the X chromosome.

If it occurs in one eye, the other eye usually experiences the same condition over the years. The genetic factor seems to be the main one and retinitis pigmentosa is hereditary in most cases.

Congenital

Retinitis pigmentosa is usually diagnosed during adolescence, but may also be present at birth. The second congenital type is usually quite stable and not progressive.  

Systemic diseases

Retinitis pigmentosa is sometimes associated with other systemic diseases such as Usher syndrome. In these cases, the doctor usually diagnoses hearing loss before visual defects.

Complications of Pigmentary Retinopathy

A Retinitis Pigmentosa in some patients may have certain complications, such as 

  • Cataract: the cataract removal can be performed for patients who are good candidates to the implantation of an intraocular lens;
  • Blindness: vision loss is due to the failure of the retinal function.

Symptoms of Pigmentary Retinopathy

There are many symptoms associated with Retinitis pigmentosa. The first symptoms of the reduced function of the photoreceptors with a difficulty of adaptation to the dark (night blindness). The patient experience this symptom when transitioning from a more luminous environment to one less luminous. This is often associated with a reduction in the peripheral field of view that causes it to bump against obstacles laterally.

Patients find it difficult to identify the people placed on the side. In a later stage, dazzle may appear and a reduction of the sight that can even reach the blindness can arise.

Other symptoms associated with RP

People with RP may experience other health problems that arise at a certain stage throughout the disease development

  • Hard time reading printed text;
  • Night vision impairment;
  • Tunnel vision, a central vision or a peripheral vision;
  • Difficulty recognizing shapes in images;
  • Glare in the eyes.

How is Retinitis Pigmentosa Diagnosed?

If you suspect that your visual difficulties are due to a case of retinitis pigmentosa, you should contact the ophthalmologist. Only the specialist can carry out all the necessary examinations to accurately identify the pathology. 

The fundoscopic examination

Its purpose is to evaluate the retinal morphology and to investigate the presence of characteristic pigment spots on the retinal surface. Some forms of retinitis do not include the presence of spots on the bottom of the eye as symptoms.

The ophthalmologist usually associate the diagnosis with specific instrumental examinations that aims to evaluate the rods’ function. It is also associated with the electroretinography (ERG) that records the retinal electrical activity.

The visual field test

The best eye doctors can evaluate the retinal sensitivity to a luminous stimulus in the various areas of the retina. It is useful to have an objective documentation of the difficulties perceived by the patient.

The visual field test evaluates the extent of visual capacity in space. On the other hand, the optical coherence tomography OCT highlights the individual layers of the retina. Thus, the deficiencies of the rods can be highlighted.

Retinitis Pigmentosa Cure & Treatment options

Nowadays, there are several Retinitis Pigmentosa cure options available. Numerous therapeutic attempts have been made to treat retinitis pigmentosa, including medical means.

The retinitis pigmentosa therapy techniques include:

  • Administration of vasodilators;
  • Anticoagulants;
  • Hyperbaric oxygen therapy;
  • Ozone therapy;
  • Vitamins;
  • Minerals;
  • Hormones;
  • Acupuncture;
  • Ultrasound;
  • Electrical stimulation.

Options of Retinitis Pigmentosa Therapy: Which one is effective?

All the techniques aim at improving blood supply and retinal metabolic process, but none was really effective. There are some options that can slow vision loss and even restore sight to some extent. The cost of the therapy varies depending on the method of the treatment that is employed.

Retinitis Pigmentosa Therapy: Best Methods

Some leading clinics and hospitals started using innovative ways in curing Retinitis Pigmentosa. These approaches include:

  • Gene therapy;
  • Anti-apoptotic agents;
  • Ribozyme therapy.

Retinitis Pigmentosa Cure & Prevention of Blindness

For patients who have become blind due to retinitis pigmentosa, the bionic eye represents an effective solution. The latter aims to improve the quality of their life. With our ophthalmology clinics, the patient could regain a good degree of autonomy through visualizing obstacles and objects.

Added to that, the new CRISPR technology can be used in the future to treat retinitis pigmentosa.

The technique can repair the genetic mutation that is the main factor of the disease. It has a great potential but is not 100% accurate. It must be verified that stem cells differentiates correctly into retinal cells. Furthermore, it is also necessary to make sure that CRISPR does not cause undesired genetic changes in the cells.

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Frequently asked questions

It is a genetic, chronic and progressive eye disease. It causes gradual degeneration of the photoreceptor cells in the retina, that are responsible for night vision (the rods).

  • Vision problems when the light decreases (night blindness);
  • Decreased visual field (tunnel vision);
  • Color perception disorders (achromatopsia);
  • In the most advanced cases, the disease can lead to cataracts (opacification of the crystallin).
  • Wearing suitable protective and filtering glasses (anti UV);
  • A supply of vitamin A and E to slow down the deterioration of cones and rods.

The epiretinal prosthesis in our partner clinics in Turkey is an "artificial retina" implanted in the patient's eye. Its role is to replace the photoreceptor cells of the retina (rods and cones).

The prosthesis is associated with small cameras (in the form of glasses) and a microcomputer placed in the patient's pocket. This device converts the visual information captured by the glasses into electrical signals, which are transmitted by radio waves to a receiver placed on the eye.

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