Hepatic transplantation or liver grafting is an allograft process. It's considered as a surgical treatment option for final-stage liver disease and acute liver failure. This is a very delicate surgery in which the surgeon takes a liver or a part of it from a living donor or brain-dead in most cases, to graft it into a body's receiver. Added to that, the doctor must ensure its good functionality. According to a study, patients with a grafted liver have an 89% chance of surviving after the first year. The survival rate of the five following years is 75 %.
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- People with liver damage caused by chronic viral hepatitis
- People with non-alcoholic fatty liver disease or primary biliary cirrhosis
- People in need of tumor removal
- Rejection of the liver
- Vascular and biliary complications
- Complications related to anesthesia
- Between 5 and 8 hours
- A month of rest for the patient and the donor
- Total recovery after 6 months
What is a liver transplant?
Liver transplantation is a treatment that can cure several diseases (e.g., cirrhosis) and cancers that can damage the liver. The surgery mainly consists of replacing the affected liver with a healthy one from a dead person in usual. The two parts must be compatible by belonging to the same blood group. This technique should be performed when the liver can no longer execute its essential functions, thus presenting a major risk to the individual health. Turquie Santé offers you the best competitive liver transplant cost in Turkey with premium service quality.
What are the indications for kidney transplant surgery?
Hepatic grafting indications are:
- Liver chronic cholestatic diseases: namely, primary biliary cirrhosis, sclerosis cholangitis, and biliary atresia
- Hepatic parenchymal diseases: cirrhosis post hepatitis or autoimmune cirrhosis or alcoholic cirrhosis
- Fulminant and sub fulminant hepatitis
- Liver primary cancer
- A genetic metabolic disease (Wilson's disease, alpha-1-antitrypsin deficiency, hemochromatosis ...)
What are the contraindications of Hepatic Grafting?
In some conditions, hepatic grafting surgery cannot be performed. Liver grafting contraindications include:
- Severe pulmonary or cardiovascular disease;
- Drug addiction or alcoholism;
- Psychosocial problems that might prevent patients from following their medical regimens after grafting;
- Presence of neoplasia;
- Diabetes, digestive and kidney disease;
- HIV infection.
Orthotopic & Domino Hepatic grafting
There are two main types of liver transplants, which are the orthotopic and the domino one.
What is an orthotopic liver transplant in Turkey?
Orthotopicliver transplant in Turkey (OLT) is a technique in which the original liver is removed and replaced by the donated one. This must be done in the same anatomical spot as the native liver. The surgery is very complicated, requiring careful crop of the donated liver and meticulous placement into the recipient. The donor's liver is connected by anastomosis at the vascular sites, with care taken to conserve hepatic blood vessels. The gall duct is usually linked to the recipients. However, a choledochojejunostomy (connection of the common bile duct to the jejunum) may be performed.
What is a domino liver transplant?
DLT or dominoliver transplant in Turkey is transferring a liver from a patient presenting a metabolic disease. The receiver is a patient with end-stage hepatic disease. This aims to reduce the effect of the recurrent syndrome in the recipient who will not develop metabolic syndrome. In a domino hepatic grafting, you receive the organ from a donor who has amyloidosis.
How is the intervention performed in Turkey?
The patient must be well-prepared for hepatic grafting. A preoperative assessment is requested by the surgeon. A general pre-anesthesia consultation is mandatory. Generally, the donor and the recipient must be relatives and have the same blood type. Therefore, an immunological assessment of the donor and the recipient are requested. Several additional examinations must be carried out between blood and radiological report. Moreover, the cross-match between the receiver and the donor must be negative (called the rejection test). To prevent rejection, two to three immunity inhibitors are associated. Corticosteroids, azathioprine, ciclosporins, and mycophenolate are indicated, and three of them are selected. The grafting is performed in an operating room while respecting the rules of strict aseptic to prevent any risk of infection.
What are the main Complications of this surgery?
Some risks and complications may occur after this surgery, such as:
- An immediate rejection of the graft;
- The primary non-functioning of the graft;
- Vascular complications: arterial thromboses;
- Biliary complications (fistulas or stenosis or ischemic sclerosing cholangitis ...);
- Infectious complications;
- Complications related to immunity inhibitor treatment: cortico-induced diabetes, high blood pressure, renal failure, cancer induced by immunity inhibitor treatment;
- Complications related to anesthesia.
The hospital stay must be in a resuscitation environment. Visits are prohibited because of the risk of infectious contamination. It is also necessary to follow the living donor with a physical examination and some additional examinations. Regular checks are mandatory. The gastrointestinal doctor follows his grafted patients. At each visit, he carries out a complete examination. It begins with the questioning and the physical examination, and he asks for additional examinations. Monitoring the function of the graft, and the search for adverse effects and complications, are the objectives of this follow-up.
Liver transplant cost in Turkey & Istanbul: Affordable Price
Liver transplantation in clinics and hospitals in Turkey is the effective treatment of chronic terminal liver disease of all etiologies. It is therefore necessary to continue the organ donation procedures. The liver transplant cost in Turkey depends on several factors. You can request your personalized quote. We'll help you get the best costs with the best doctors in our partner clinics and hospitals in Turkey.
You will find below a comparison between the prices of liver grafting in Turkey and other countries:
|Country||Liver transplant cost|
|United States of America||260,000 euros|
|Turkey (Turquie santé)||50,000 euros|
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The donor must be a relative to the patient and the liver transplant is done following a donation. There is no question of buying or selling an organ.
- Be a relative to the receiver patient;
- Be under 60 years old;
- Not be overweight;
- Not having chronic illnesses.
The liver is the only organ that can regenerate itself. As a result, the liver cells (hepatocytes) of the living donor could reconstitute the parts removed from the liver of this one.
With a transplanted liver, you can live as normally as possible: except that certain rules must be respected, such as having a certain hygiene of life and taking certain medications for life.
Just like a kidney transplant and a heart transplant, a liver transplant involves genetic compatibility. The blood group of the donor and the recipient must also be the same.
After liver transplantation, hospitalization for 15 days under intensive care would be necessary.
For the donor, this procedure requires hospitalization for 7 days.
It is 97%.