Gastroesophageal reflux disease treatment in Turkey, Prices of Istanbul Clinics 2025

Gastroesophageal reflux disease (GERD): What is it?

Gastroesophageal reflux disease (GERD) is a common digestive disorder caused by the backflow of stomach acid into the esophagus. This acid irritates the lining of the esophagus, causing a variety of symptoms that may be more or less severe in some people.

Typical reflux symptoms include:

• Retrosternal (behind the breastbone) burning.
• Acid regurgitation.
• Chest pain after meals.
• Difficulty breathing.

But GERD can also be more subtle, with "atypical" symptoms: a persistent cough, sore throat, hoarse voice, or difficulty sleeping.

It's normal to have occasional small flare-ups. However, if these symptoms become regular or daily, it may be a sign of pathological reflux that requires medical attention.

When should you be concerned?

When GERD symptoms become recurrent (several times a week),a simple lifestyle change is no longer enough. In 30 to 35% of cases, reflux can lead to complications such as:

• Inflammation of the esophagus (esophagitis).
• Esophageal ulcers.
• Esophageal strictures.
• Early diagnosis and appropriate medical treatment are essential to avoid these risks.

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Causes of gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is a complex pathology resulting from a number of factors including dietary, anatomical, functional, hormonal and pharmacological. By understanding the underlying causes of GERD, we can better prevent and treat this troublesome condition.

Dietary factors

Certain foods can cause or worsen reflux by reducing pressure on the lower esophageal sphincter, the natural barrier between the esophagus and stomach. Fatty, spicy, and acidic foods, as well as beverages such as coffee and alcohol, are often responsible for the buildup of stomach acid in the esophagus.

Anatomical factors

Abnormalities in the lower esophageal sphincter, which controls the passage of food between the esophagus and stomach, can lead to reflux. When this sphincter becomes too weak or dysfunctional, it cannot maintain the pressure needed to prevent acid from flowing back up the esophagus.

Functional factors

The proper functioning of your digestive system depends on the motility of your esophagus and stomach. When these organs don't contract properly to expel food, acid reflux becomes more likely.

Hormonal Factors

Hormonal changes can also play an important role in the onset of reflux. For example, during pregnancy, increased levels of certain hormones can weaken the esophageal sphincter, making acid reflux easier.

Pharmacologic factors

Certain medications, such as muscle relaxants, anticholinergics, or antihypertensives, can decrease pressure on the esophageal sphincter, making it easier for stomach acid to reflux.

High intra-abdominal pressure

Excessive abdominal pressure, often associated with overweight, obesity, or pregnancy, can also promote reflux. When abdominal pressure increases, it pushes stomach acid toward the esophagus, causing GERD symptoms.

Diagnosis of gastroesophageal reflux disease in Turkey

Gastro-oesophageal reflux disease (GERD) is a common but complex condition that requires accurate diagnosis to avoid long-term complications. In Turkey, specialized clinics offer high-quality testing to quickly identify GERD and determine the best treatment.

X-ray of the digestive tract

An X-ray of the digestive tract is often the first test performed to observe the anatomy and function of the esophagus and stomach. By having the patient drink a contrast liquid, this test can detect abnormalities in the structure of the digestive system, such as obstructions or acid reflux. The test is quick, non-invasive, and provides a useful overview for physicians.

Gastroscopy (EGD)

Gastroscopy is a key test in the diagnosis of GERD. Using a flexible endoscope, a doctor can directly examine the esophagus, stomach, and duodenum for signs of inflammation, ulcers, or other lesions. If necessary, biopsies can be taken for a more accurate diagnosis. This test is performed safely in Turkey's modern hospitals, providing each patient with a comfortable environment and prompt care.

Esophageal manometry

Esophageal manometry is an important test for the diagnosis of esophageal motility disorders. A thin tube is inserted through the nose to measure the strength of the esophageal contractions. This allows doctors to determine whether motility abnormalities are contributing to GERD symptoms.

Impedance pH analysis

24-hour impedance pH analysis measures acid and non-acid reflux in the esophagus. A thin probe is inserted through the nose and the test monitors reflux throughout the day and night. This test is extremely useful in cases of refractory reflux, allowing doctors to accurately determine the type of reflux and adjust treatment.

GERD treatment options in Turkey

Treatment of gastroesophageal reflux disease (GERD) begins with lifestyle and dietary changes. For persistent symptoms, several medication options and, in some cases, surgical or endoscopic treatments may be considered.

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Initial lifestyle changes to relieve GERD

The initial treatment of reflux is mainly based on lifestyle changes. Here are the most important recommendations:

• Nutrition education: Eat a balanced diet and reduce body weight, especially belly fat. Avoid foods that can increase acidity, such as chocolate, peppermint, coffee, citrus fruits, tomatoes, and alcohol.
• Stop smoking: Smoking worsens GERD symptoms by relaxing the esophageal sphincter.
• Change your eating habits: Don't go to bed right after eating, especially after a heavy meal. Wait at least 3 hours before going to bed and choose a light meal in the evening.

If these changes don't relieve your symptoms, you may be prescribed medication to control stomach acid.

Medications to treat gastro-oesophageal reflux disease (GERD)

Several classes of medication can be used to treat GERD, depending on the severity of symptoms:

• Antacids: These drugs neutralize the acid in the stomach, bringing rapid relief from heartburn. However, they do not heal damage to the esophagus and are only useful for temporary relief of symptoms. Overuse of antacids can lead to side effects such as diarrhea or constipation.
• H2 antagonists (famotidine, ranitidine): These drugs reduce acid production and have a longer duration of action than antacids. However, their efficacy may diminish over time.
• Proton pump inhibitors (PPIs): PPIs (omeprazole, lansoprazole, rabeprazole, etc.) are often prescribed to treat esophageal erosions and reduce acidity. Their effect starts more slowly (around 48 hours),but they are more effective in healing esophageal lesions.
• Prokinetic drugs: These drugs (clebopride, domperidone, etc.) improve emptying of the esophagus and stomach, thus reducing reflux. Although effective, they can have side effects such as neurological disorders and, in some cases, increased prolactin levels.

Surgery and innovative treatments in Turkey

In cases where medication is not sufficient or there are anatomical problems such as large hiatal hernias, surgery may be considered. Laparoscopic fundoplication is an operation to strengthen the valve between the esophagus and stomach to prevent reflux. This procedure is generally reserved for patients who do not respond to medical therapy.

Minimally invasive endoscopic treatment is a newer option that is particularly effective for patients with chronic reflux. Using special instruments inserted through the mouth, it can treat GERD symptoms without invasive surgery, with quick recovery and excellent results.